{"id":12284,"date":"2024-09-13T09:37:34","date_gmt":"2024-09-13T07:37:34","guid":{"rendered":"https:\/\/iph-multisite.berta-bewegt.ch\/?p=12284"},"modified":"2026-03-03T10:33:13","modified_gmt":"2026-03-03T09:33:13","slug":"sommerblogserie-mit-dem-3rcc-teil-5-3d-gedrucktes-modell-revolutioniert-die-krebsforschung","status":"publish","type":"post","link":"https:\/\/www.interpharma.ch\/fr\/blog\/sommerblogserie-mit-dem-3rcc-teil-5-3d-gedrucktes-modell-revolutioniert-die-krebsforschung\/","title":{"rendered":"S\u00e9rie de blogs d\u2019\u00e9t\u00e9 en collaboration avec le 3RCC Partie 5: Un mod\u00e8le imprim\u00e9 en 3D r\u00e9volutionne la recherche sur le cancer"},"content":{"rendered":"\n

Bien qu\u2019il soit l\u2019une des principales causes de d\u00e9c\u00e8s, le cancer reste difficile \u00e0 traiter efficacement. Cela s\u2019explique notamment par le fait que les mod\u00e8les de recherche actuels, comme les cultures de cellules 2D1<\/sup>, les greffes de tumeurs sur des souris2<\/sup> ou les organo\u00efdes3<\/sup> cultiv\u00e9s en laboratoire, ne reproduisent pas pr\u00e9cis\u00e9ment l\u2019environnement des tumeurs, qui peut influencer la fa\u00e7on dont celles-ci r\u00e9agissent aux m\u00e9dicaments.<\/p>\n\n\n\n

Les mod\u00e8les 3D de tumeurs<\/strong>, des structures cr\u00e9\u00e9es en laboratoire qui imitent l\u2019environnement tridimensionnel des tumeurs, montrent<\/strong> plus pr\u00e9cis\u00e9ment comment les cellules tumorales interagissent avec leur environnement<\/strong>. Il s\u2019agit d\u2019un facteur important, car de nombreux m\u00e9dicaments contre le cancer ciblent justement ces interactions. Cependant, il manque encore des caract\u00e9ristiques essentielles \u00e0 ces mod\u00e8les 3D, comme des cellules de soutien et des vaisseaux sanguins, indispensables pour la croissance de la tumeur et l\u2019efficacit\u00e9 des tests de m\u00e9dicaments.<\/p>\n\n\n\n

Lena Neufeld et son laboratoire de l\u2019Universit\u00e9 de Tel-Aviv en Isra\u00ebl ont utilis\u00e9 une bio-imprimante pour cr\u00e9er un mod\u00e8le de tumeur en 3D, une structure d\u00e9velopp\u00e9e en laboratoire qui imite cet environnement tridimensionnel complexe des tumeurs. Ils ont g\u00e9n\u00e9r\u00e9 un mod\u00e8le de tumeur en 3D avec une bioarchitecture tr\u00e8s similaire aux tumeurs naturelles. <\/s><\/p>\n\n\n\n

Ce mod\u00e8le a pu imiter l\u2019architecture complexe du cancer et sa croissance, et constitue ainsi une alternative<\/strong> pr\u00e9f\u00e9rable aux mod\u00e8les animaux<\/strong>. Il peut servir de plate-forme de test pour de nouveaux traitements, en assurant davantage de pr\u00e9cision que les cultures 2D. La preuve solide de l\u2019insuffisance des cultures 2D pour mod\u00e9liser le cancer in vivo illustre la n\u00e9cessit\u00e9 d\u2019\u00e9largir davantage ce domaine de recherche et de l\u2019appliquer \u00e0 d\u2019autres secteurs. \u00c9tant donn\u00e9 que le criblage des m\u00e9dicaments dans la recherche pr\u00e9clinique sur le cancer repose principalement sur les animaux, cette \u00e9tude fournit de solides arguments en faveur d\u2019un passage \u00e0 des syst\u00e8mes bio-imprim\u00e9s en 3D dans la recherche de m\u00e9dicaments contre cette maladie.<\/p>\n\n\n\n

Auteurs: Christopher Cederroth, Jessica Lampe & Robbie I\u2019Anson Price, Swiss 3R Competence Centre<\/p>\n\n\n\n

R\u00e9f\u00e9rence:<\/strong> Neufeld L. et al., (2021) Microengineered perfusable 3D-bioprinted glioblastoma model for in vivo mimicry of tumor microenvironment. Science Advances.<\/em> 7(34):eabi9119. https:\/\/doi.org\/10.1126\/sciadv.abi9119<\/a><\/p>\n\n\n\n

1<\/sup> Une culture cellulaire 2D est une technique de laboratoire utilis\u00e9e pour d\u00e9velopper et pr\u00e9server des cellules dans un environnement plat et bidimensionnel.<\/p>\n\n\n\n

2<\/sup> Une greffe de tumeur, \u00e9galement appel\u00e9e x\u00e9nogreffe d\u00e9riv\u00e9e de patient (PDX), est un mod\u00e8le pour l\u2019\u00e9tude du cancer chez l\u2019humain. Cette technique consiste \u00e0 greffer les tissus tumoraux d\u2019un patient canc\u00e9reux \u00e0 des souris immunod\u00e9ficientes. Le syst\u00e8me immunitaire de ces souris \u00e9tant affaibli, elles ne rejettent pas les tissus humains, ce qui permet \u00e0 la tumeur de se d\u00e9velopper et d\u2019\u00eatre \u00e9tudi\u00e9e dans un organisme vivant.<\/sup><\/p>\n\n\n\n

3<\/sup> Les organo\u00efdes cultiv\u00e9s en laboratoire sont des r\u00e9pliques tridimensionnelles d\u2019organes, miniaturis\u00e9es et simplifi\u00e9es.<\/sup><\/p>\n\n\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

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