{"id":4056,"date":"2026-02-25T08:25:44","date_gmt":"2026-02-25T07:25:44","guid":{"rendered":"https:\/\/iph-multisite.berta-bewegt.ch\/?page_id=4056"},"modified":"2026-02-25T08:25:44","modified_gmt":"2026-02-25T07:25:44","slug":"phase-preclinique","status":"publish","type":"page","link":"https:\/\/www.interpharma.ch\/fr\/themen\/a-la-pointe-de-la-recherche-et-developpement\/le-long-chemin-vers-un-medicament\/phase-preclinique\/","title":{"rendered":"Phase pr\u00e9clinique"},"content":{"rendered":"\n<p>Avant de pouvoir tester un\ncandidat m\u00e9dicament chez l\u2019\u00eatre humain dans le cadre d\u2019un essai clinique, il\ndoit passer ce que l\u2019on appelle un programme de d\u00e9veloppement pr\u00e9clinique. Il\ns\u2019agit de tester si la substance a des effets n\u00e9gatifs, par exemple si elle est\ntoxique, provoque des cancers ou des modifications du patrimoine g\u00e9n\u00e9tique.\nPour ces tests, on emploie d\u2019abord des cultures cellulaires, plus tard\n\u00e9galement des exp\u00e9riences sur animaux. <\/p>\n\n\n\n<p>Il faut que la substance ait\npass\u00e9 avec succ\u00e8s toutes les exp\u00e9riences pr\u00e9cliniques prescrites avant de\npouvoir \u00eatre test\u00e9e chez l\u2019\u00eatre humain. C\u2019est-\u00e0-dire qu\u2019elle doit s\u2019\u00eatre av\u00e9r\u00e9e\ninoffensive en culture cellulaire, puis chez l\u2019animal. Les exp\u00e9riences\nrespectent des directives accept\u00e9es \u00e0 l\u2019\u00e9chelon international (directives de\nl\u2019ICH) et sont orient\u00e9es conform\u00e9ment aux principes des 3R (Replace, Reduce,\nRefine). <\/p>\n\n\n\n<p>En phase pr\u00e9clinique, les essais\nsuivants doivent \u00eatre r\u00e9alis\u00e9s:<\/p>\n\n\n\n<ul class=\"post wp-block-list\"><li>essais pharmacologiques,<\/li><li>essais de toxicit\u00e9 g\u00e9n\u00e9rale,<\/li><li>essais de toxicocin\u00e9tique et pharmacocin\u00e9tique et<\/li><li>essais de toxicit\u00e9 \u00e0 dose r\u00e9p\u00e9t\u00e9e.<\/li><\/ul>\n\n\n\n<p>Certains autres essais\npr\u00e9cliniques sont r\u00e9alis\u00e9s le cas \u00e9ch\u00e9ant, en fonction des conditions\nsp\u00e9cifiques, par exemple l\u2019\u00e9valuation de la phototoxicit\u00e9 (d\u00e9clenchement d\u2019une\nr\u00e9action cutan\u00e9e sous l\u2019effet de la lumi\u00e8re).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Avant de pouvoir tester un candidat m\u00e9dicament chez l\u2019\u00eatre humain dans le cadre d\u2019un essai clinique, il doit passer ce que l\u2019on appelle un programme de d\u00e9veloppement pr\u00e9clinique. Il s\u2019agit de tester si la substance a des effets n\u00e9gatifs, par exemple si elle est toxique, provoque des cancers ou des modifications du patrimoine g\u00e9n\u00e9tique. Pour [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":4286,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"page-templates\/unterthema.php","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-4056","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.2 (Yoast SEO v27.2) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Phase pr\u00e9clinique - Interpharma<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.interpharma.ch\/fr\/themen\/a-la-pointe-de-la-recherche-et-developpement\/le-long-chemin-vers-un-medicament\/phase-preclinique\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Phase pr\u00e9clinique\" \/>\n<meta property=\"og:description\" content=\"Avant de pouvoir tester un candidat m\u00e9dicament chez l\u2019\u00eatre humain dans le cadre d\u2019un essai clinique, il doit passer ce que l\u2019on appelle un programme de d\u00e9veloppement pr\u00e9clinique. Il s\u2019agit de tester si la substance a des effets n\u00e9gatifs, par exemple si elle est toxique, provoque des cancers ou des modifications du patrimoine g\u00e9n\u00e9tique. 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